Erythema annulare centrifugum3 is the term most often used for all gyrate erythemas except erythema marginatum, erythema chronicum migrans, and erythema gyratum repens. Erythema gyratum repens associated with cryptogenic. Erythema gyratum repens is most often present in caucasian men in their 60s. These images are a fentrifugo sampling from a bing search on the term erythema annulare centrifugum. Bullous lupus erythematosus is a rare clinical form of lupus. Erythema gyratum repens is rare and is the most distinctive of the gyrate erythemas. Erythema gyratum repens is a clinically distinctive figurate or annular erythema that is usually associated with underlying malignancy. Erythema anulare centrifugum eac, is a descriptive term for a class of skin lesion presenting redness in a ring form anulare that spreads from a center centrifugum. Deep form is usually lupus tumidus or erythema migrans. Learn indepth information on erythema gyratum repens associated with systemic lupus erythematosus, its causes, symptoms, diagnosis, complications, treatment, prevention, and prognosis. It can be caused by a variety of conditions, and typically resolves spontaneously within 30 days. Erythema gyratum repens occurs as concentric erythematous plaques with fine scales, resembling a woodgrain pattern.
Some of the types include annular erythema deep and superficialerythema perstans, erythema gyratum perstans, erythema gyratum repens, darier erythema deep gyrate erythema and erythema figuratum perstans. Erythema gyratum repens presents with concentric erythematous rings that have a distinctive woodgrain appearance. The most common include lung carcinoma, oesophageal carcinoma and breast carcinoma. Erythema gyratum repens induced by pegylated interferon alfa. Erythema gyratum repens definition of erythema gyratum. Histopathology revealed a superficial perivascular and somewhat lichenoid lymphoid infiltrate, consistent with mycosis fungoi.
Nov 22, 2011 erythema gyratum repens egr is a rare and characteristic, paraneoplastic rash associated with a variety of malignancies, most notably lung, esophageal, and breast cancers. A succinct summary of the patients history, examination and initial investigations, including fullcolour images showing presentation, is followed. Erythrokeratoderma en cocardes with r32w mutation in gjb3. Erythema gyratum repens egr most often represents a paraneoplastic figurate erythema.
Erythema gyratum repens egr, first described by gammel,1 in 1952, is a rare paraneoplastic syndrome typically associated with an underlying malignancy. Erythema gyratum repens associated with systemic lupus. Erythema gyratum repens is associated with malignancy in as many as 80% of patients. Erythema gyratum repens unassociated with internal malignancy.
In order to deliver a personalised, responsive service and to improve the site, we remember and store information about how you use it. Following the resection, the skin lesions cleared within a few days. Although most cases of egr are associated with underlying malignancy, several nonparaneoplasticassociated cases of egr have. Erythema gyratum repens egr is a rare paraneoplastic skin condition characterized by the eruption of expanding, concentric, erythematous patches and plaques. This case report details the appearance, epidemiology, diagnosis, and treatment of egr. Although most cases of egr are associated with underlying malignancy, several. The rings progress in waves, with the leading edge migrating about 1 cmday. Erythema gyratum repens egr is a rare cutaneous eruption characterized by serpiginous morphology and a migrating scaly border. Erythema gyratum repens egr is a rare and poorly understood dermatosis.
Erythema gyratum repens erg is a distinctive dermatitis often associated with paraneoplastic syndrome. Erythema annulare centrifugum erythema marginatum erythema migrans erythema gyratum repens. Erythema gyratum repens egr is a figurate erythema known to be a paraneoplastic process characterized by concentric erythematous bands forming woodgrain pattern. Erythema gyratum repens as the initial manifestation of lung. The eruption is rapidly migrating and composed of concentric rings forming a woodgrain pattern. Erythema gyratum repens associated with diffuse bcell. Histological features of erythema gyratum repens are not diagnostic and include hyperkeratosis, parakeratosis, acanthosis and. Gammel syndrome paraneoplastic disorder resulting in erythematous lesions associated with neoplasms of internal organs. Erythema gyratum repens eruption has been noted after surgery, chemotherapy, or radiotherapy. Erythema gyratum repens u pacientky s duplicitnou malignitou.
Almost half of the patients with erythema gyratum repens have lung cancer 3347%, and less commonly, oesophageal, breast, and stomach cancer 1,2. Erythema gyratum repens associated with tuberculosis. The eruption is rapidly migrating and composed of concentric rings forming a woodgrain pattern histology of erythema gyratum repens. In addition to other features, characteristic concentric erythematous bands forming a woodgrain appearance see the image below help distinguish erythema gyratum repens from other figurate erythemas. It occurs with any skin injury, infection, or inflammation. Erythema gyratum repens egr is a figurate erythema that is believed to be a paraneoplastic process. Autoantibodies and complement at the basement membrane zone of the skin was found which suggest that erythema gyratum repens may have an immunological pathogenesis but the nature of the antigen should be further characterised.
Erythema gyratum repens with pulmonary tuberculosis. This unusual form of figurate erythema has been associated with malignant hematologic diseases and with carcinomas of the breast, lung, gastrointestinal tract, prostate, and cervix. Erythema gyratum repens is a figurate erythema that is rapidly moving and usually a marker of underlying cancer. We report a 46yearold afrocaribbean man with the unequivocal clinical and histological features of. Specific disease entities in in the group of gyrate erythemas include.
Full text full text is available as a scanned copy of the original print version. Background erythema gyratum repens egr is a rare clinical entity that is considered to be an obligatory paraneoplastic disease. Aai3 193b iournal of the american academy of dermatology volume 12 number 5 part 2 may, 1985 iiii erythema gyratum repens unassociated with internal malignancy joseph c. The authors present a patient with erythema gyratum repens who had a bronchogenic carcinoma. Erythema gyratum repens an immunological paraneoplastic. Volume 47, issue 5, supplement, november 2002, pages s254s256. This is done using simple text files called cookies which sit on your computer. Erythema annulare centrifugum eac is a chronic, reactive phenomenon of the skin presenting with arcuate or annular, erythematous patches or thin plaques that frequently exhibit scale along the inner portion of the advancing edge of lesions trailing scale picture 1ad. Erythema gyratum repens egr is a rare, and characteristic, paraneoplastic rash associated with a variety of malignancies, most notably lung, esophageal, and breast cancers. Erythema anulare centrifugum eac, is a descriptive term for a class of skin lesion presenting redness erythema in a ring form anulare that spreads from a center centrifugum. The term was originally used by darier in 19164 and defines a clinical disorder manifested by solitary or multiple annular, erythematous lesions, which may spread.
Erythema migrans represents the initial cutaneous manifestation of lyme disease, an infection due to b. Erythema gyratum repens egr is a rare clinical entity that is considered to be an obligatory paraneoplastic disease. Seattle, wa a case report of erythema gyratum repens occurring in a 68yearold man is presented. Institute for pathology georg schmorl academic teaching hospital dresdenfriedrichstadt, stadtisches klinikum, dresden, germany. According to the literature, an underlying neoplasm can be detected in 82% of the cases. May 08, 2015 the abdomen should be examined for tenderness, masses, or hepatosplenomegaly. Erythema gyratum definition of erythema gyratum by medical. It is known to be associated with a variety of malignancies such as lung cancer, esophageal cancer, and breast cancer. Prompt identification of egr is essential, as the rash often precedes the diagnosis of malignancy by several months. Transitional carcinoma of the kidney lung adenocarcinoma.
Authors describe a case report of female patient with renal cell carcinoma and chronic lymphocytic leukemia. Erythema gyratum repens an overview sciencedirect topics. Get a printable copy pdf file of the complete article 490k, or click on a page image below to browse page by page. Eubanks le, mcburney e, reed r 2001 erythema gyratum repens. Erythema gyratum repens as the initial manifestation of lung cancer erythema gyratum repens is a rare reactive erythema and most cases are associated with internal malignancies 1. Erythema gyratum repens egr is a rare and characteristic, paraneoplastic rash associated with a variety of malignancies, most notably lung, esophageal, and breast cancers. Erythema gyratum repens in a case of resolving psoriasis. Bullous lupus erythematosus is an autoantibodymediated subepidermal blistering disease that occurs in patients with systemic lupus erythematosus sle. Erythema gyratum repens associated with anal cancer list of authors. The figurate erythemas include a variety of eruptions characterized by annular and polycyclic lesions.
Mar 27, 2019 erythema gyratum repens egr is a figurate erythema that is believed to be a paraneoplastic process. According to the literature, an underlying neoplasm can be. In the majority of instances cancer is the culprit, however, certain autoimmune diseases or infections may give rise to the. Full text is available as a scanned copy of the original print version. Diagnosis of erythema annulare centrifugum is one of the exclusions. Erythema gyratum repens has not previously been described in association with non. Figurate erythema, erythema annulare centrifugum, erythema gyratum repens, erythema migrans, necrolytic migratory erythema. Paraneoplastic skin syndromes melissa piliang, md dermatology and anatomic pathology cleveland clinic. The relationship of superficial dermatophytic infection to egrlike eruptions in mycosis fungoides mf is unclear. The diagnosis is challenging and involves the exclusion of other subepidermal bullous dermatoses. Erythema gyratum repens appears as concentric, scaly bands of erythema in a gyrate pattern, forming a wood grain appearance. Bronchiolar carcinoma presenting as erythema gyratum perstans. Leukocytoclastic vasculitis presenting as an erythema gyratum repens like eruption on a patient with systemic lupus erythematosus. Superficial and deep variants can be separated clinically and histologically.
An erythema gyratum repens variant of bullous lupus. A 54yearold male was admitted due to peculiar figurate erythemas mainly located on the lower legs. It is associated with internal malignancy in 82% of patients. The rash can appear either before or after detection of the malignancy. Large, annular scaly plaques, most commonly on the trunk of adults. Jan 26, 2020 some of the types include annular erythema deep and superficialerythema perstans, erythema gyratum perstans, erythema gyratum repens, darier erythema deep gyrate erythema and erythema figuratum perstans. Erythema gyratum repens is a figurate erythema that is rapidly moving and usually a marker of underlying cancer, usually from the lung. The photos of erythema gyratum repens below are not recommended for people with a weak psyche. Erythema gyratum repens is a rare, clinically specific, and distinctive paraneoplastic syndrome. Erythema gyratum repens is rare, inflammatory skin disease belonging to the group of paraneoplastic disorders. Clinical appearance is important to establish the diagnosis. Bullous lupus erythematosus with an erythema gyratum. Leukocytoclastic vasculitis presenting as an erythema.
July pages a skin biopsy can be performed to test for eac. Get a printable copy pdf file of the complete article 644k, or click on a page image below to browse page by page. Get a printable copy pdf file of the complete article 97k, or click on a page image below to browse page by page. Neutrophilic dermatosis, bullous dermatoses, and systemic lupus erythematous gyratum repens 3. Perivascular lymphocytic infiltrate of variable density, slight spongiosis and parakeratosis. The most common underlying neoplasms are from lung, breast, or esophagus. These may represent liver disease, lymphoma or pregnancy associated with erythema annulare centrifugum eac. Bullous lupus erythematosus with an erythema gyratum repens.
In addition, there is some types of gyrate erythema could be misdiagnosed as egr such as. Erythema gyratum repens induced by pegylated interferon. In addition to other features, characteristic concentric erythematous bands forming a woodgrain appearance help distinguish erythema gyratum repens from other figurate erythemas, such as erythema annulare centrifugum, erythema migrans, and e. We present a 21yearold woman with erythematosus, polycyclic plaques with vesiculobullae along the periphery, creating an erythema gyratum repens like pattern on acral regions. Links to pubmed are also available for selected references. Among visceral malignancies, the lung is the most common site, 7, 8, 9 followed by the breast, urinary bladder, uterus andor cervix, gi tract stomach, and prostate. Erythema gyratum repens associated with pityriasis rubra. Erythema gyratum repens egr is an uncommon condition defining a type of skin lesion pattern, in which red skin rashes composed of concentric rings annular erythema moves. There are many types of erythema, or conditions causing rash and reddening of the skin, but erythema gyratum repens typically appears because of an underlying condition. We wish you a cure and never get sick of this disease.
Here, we report a case of erythema gyratum repens occurring in a patient with cryptogenic organizing pneumonia. It is one of the most specific cutaneous paraneoplastic phenomena, and is associated with malignancy in most cases. A cavitating mass at the right lung apex was resected and proved to be tuberculous. Erythema gyratum repens is not an obligate paraneoplastic. Etiology and therapeutic management of erythema nodosum during pregnancy. Erythema nodosum en, is an inflammatory condition characterized by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins. Erythrokeratoderma en cocardes 4 and erythokeratoderma with erythema gyratum repens like lesions 5 are considered to be clinical variants of ekv, characterized by figurate, polycyclic and concentric cockadelike lesions that vary in shape in the course of hours or days and tend to recur in the course of several weeks, in association. Erythema annulare centrifugum tends to recur over several months or years, but it can spontaneously remit. A 73yearold woman presented with an evolving pruritic, erythematous rash and was. Erythema gyratum repens associated with tuberculosis is associated with underlying tuberculosis, which is a contagious infection caused by the bacterium mycobacterium tuberculosis. Erythema gyratum repens associated with anal cancer nejm. Erythema gyratum repens is a figurate erythema with a characteristic wood grain pattern and rapid peripheral spread. There is an associated underlying malignancy in 80% of patients with erythema gyratum repens.
1016 36 988 1050 1246 1523 359 92 418 823 917 1305 961 849 212 1408 523 703 1267 692 801 1072 796 82 669 1416 1167 1344 104 1102 163 807